Publications

1. Thomas, W. M., Zuniga, S. A., Sondh, I., Leber, M., Solzbacher, F., Lenarz, T., Lim, H. H., Warren, D. J., Rieth, L., and Adams, M. E.. Development of a feline model of preclinical research of a new translabyrinthine auditory nerve implant. Frontiers in Neuroscience 18 (2024).
2. Gloeckner CD, Nocon JC, Lim HH (2022) Topographic and widespread auditory modulation of the somatosensory cortex: Potential for bimodal sound and body stimulation for pain treatment. Journal of Neural Engineering 19.
    
3. Conlon B, Hamilton C, Meade E, Leong SL, O Connor C, Langguth B, Vanneste S, Hall DA, Hughes S, Lim HH (2022) Different bimodal neuromodulation settings reduce tinnitus symptoms in a large randomized trial. Scientific Reports 12(1): 10845.
    
4. Richardson KL, Teague CN, Mabrouk S, Nevius BN, Ozmen GC, Graham R, Zachs DP, Tuma A, Peterson E, Lim HH, Inan O (2022) Quantifying rheumatoid arthritis disease activity using a multimodal sensing knee brace. IEEE Transactions on Biomedical Engineering, DOI: 10.1109/TBME.2022.3177074.
    
5. Hongsun G, Offutt SJ, Hamilton II M, Kim Y, Gloeckner CD, Zachs DP, Alford JK, Lim HH (2022) Ultrasound does not activate but can inhibit in vivo mammalian nerves across a wide range of parameters. Scientific Report 12(1): 1-14.
    
6. Mahmoodi SR, Xie P, Zachs DP, Peterson EJ, Graham RS, Kaiser CRW, Lim HH, Allen MG, Javanmard M. Single-step label-free nanowell immunoassay accurately quantifies serum stress hormones within minutes. Science Advances 7(27). doi: 10.1126/sciadv.abf4401. article.
    
7. Dirk De Ridder, Winfried Schlee, Sven Vanneste, Alain Londero, Nathan Weisz, Tobias Kleinjung, Giriraj Singh Shekhawat, Ana Belén Elgoyhen, Jae Jin Song, Gerhard Andersson, Andreia Aparecida de Azevedo, David M. Baguley, Eberhard Biesinger, Ana Carolina Binetti, Luca Del Bo, Christopher R. Cederroth, Rilana Cima, Jos J. Eggermont, Ricardo Figueiredo, Thomas E. FullerShow lessSilvano Gallus, Annick Gilles, Deborah A. Hall, Paul Van de Heyning, Derek J. Hoare, Eman M. Khedr, Dimitris Kikidis, Maria Kleinstaeuber, Peter M. Kreuzer, Jen Tsung Lai, Jose Miguel Lainez, Michael Landgrebe, Lieber Po Hung Li, Hubert H. Lim, Tien Chen Liu, Jose A. Lopez-Escamez, Birgit Mazurek, Aage R. Moller, Patrick Neff, Christo Pantev, Shi Nae Park, Jay F. Piccirillo, Timm B. Poeppl, Josef P. Rauschecker, Richard Salvi, Tanit Ganz Sanchez, Martin Schecklmann, Axel Schiller, Grant D. Searchfield, Richard Tyler, Veronika Vielsmeier, Johan W.S. Vlaeyen, Jinsheng Zhang, Yiwen Zheng, Matteo de Nora, Berthold Langguth. (2021). Tinnitus and tinnitus disorder: Theoretical operational definitions (an international multidisciplinary proposal). In Winfried Schlee, Berthold Langguth, Tobias Kleinjung, Sven Vanneste, Dirk De Ridder (Eds.), Tinnitus - An Interdisciplinary Approach Towards Individualized Treatment (pp, 1-25).Elsevier BV. link.
    
8. Hosseini M, Rodriguez G, Guo H, Lim HH, Plourde E. The effect of input noises on the activity of auditory neurons using GLM-based metrics. J Neural Eng. 2021 Feb 23. doi: 10.1088/1741-2552/abe979. Online ahead of print. PMID: 33626516. Article.
    
9. Conlon B, Langguth B, Hamilton C, Hughes S, Meade E, Conno CO, Schecklmann M, Hall DA, Vanneste S, Leong SL, Subramaniam T, D'Arcy S, Lim HH. Bimodal neuromodulation combining sound and tongue stimulation reduces tinnitus symptoms in a large randomized clinical study. Science Translational Medicine. 12(564). doi: 10.1126/scitranslmed.abb2830. article.
    
10. Graham RS, Zachs DP, Cotero V, D'Agostino C, Ntiloudi D, Kaiser CRW, Graf J, Wallace K, Ramdeo R, Coleman TR, Ashe J, Pellerito J, Tracey KJ, Binstadt BA, Chavan SS, Zanos S, Puleo C, Peterson E, Lim HH. First-in-human demonstration of splenic ultrasound stimulation for non-invasively controlling inflammation. (posted on medRxiv while in review with a journal)
     
11. Conlon B, Hamilton C, Hughes S, Meade E, Hall DA, Vanneste S, Langguth B, Lim HH. Noninvasive bimodal neuromodulation for the treatment of tinnitus: Protocol for a second large-scale double-blind randomized clinical trial to optimize simulation parameters. JMIR Research Protocols 8(9):e13176,2019.
     
12. Lenarz T, Samii A, Dyballa KH, Lim HH. Auditory Midbrain Implant In: Auditory Brainstem Implants, edited by Wilkinson EP, Schwartz MS. Published by Thieme Publishers, 2020.
     
13. Hosseini, M, Rodriguez G, Guo H, Lim HH, Plourde E. Novel metrics to measure the effect of additive inputs on the activity of sensory system neurons. 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society 41, 2019.
     
14. Cotero V, Graf J, Zachs DP, Tracey KJ, Ashe J, Lim HH, Puleo C. (2019) Peripheral Focused Ultrasound Stimulation (pFUS): New Competitor in Pharmaceutical Markets? SLAS Technol. 24(4). Article.
     
15. Zachs D., Offutt S., Graham R., Kim Y., Mueller J., Auger J., Schuldt N., Kaiser C., Heiller A., Dutta R., Guo H., Alford J., Binstadt B., Lim H. (2019) Noninvasive ultrasound stimulation of the spleen to treat inflammatory arthritis. Nature Communications (10). Article.
     
16. Stahn P., Lim HH., Hinsberger MP., Sorg K., Pillong L., Kannengieber M., Schreiter C., Foth HG., Langenbucher A., Schick B., Wenzel GI. (2019). Frequency-specific activation of the peripheral auditory system using optoacoustic laser stimulation. Scientific Reports (9). Article.
     
17. Xu, J., Guo, H., Nguyen, A., Lim, H., Yang, Z. (2018). A Bidirectional Neuromodulation Technology for Nerve Recording and Stimulation. Micromachines 9,538. Article
     
18. Guo H, Hamilton M, Offutt SJ, Gloeckner CD, Li T, Kim Y, Legon W, Alford JK, Lim HH. "Ultrasound produces extensive brain activation via a cochlear pathway." Neuron, 2018. Article
     
19. Xu J, Nguyen AT, Zhao W, Guo H, Wu T, Wiggins H, Keefer E, Lim HH, Yang Z. "A low-noise, wireless, frequency-shaping neural recorder." IEEE Journal on emerging and Selected Topics in Circuits and Systems, 2018. Abstract
     
20. Lim HH, Adams ME, Nelson PB, Oxenham AJ. Restoring Hearing with Neural Prostheses: Current Status and Future Directions. In: Neuroprosthetics: Theory and Practice, edited by Horch KW, Kipke DR. Published by World Scientific Publishing Co., 2017.
     
21. Wu, T., Zhao, W., Guo, H., Lim, H.H., & Yang, Z. (2017). A Streaming PCA VLSI Chip for Neural Data Compression. IEEE transactions on biomedical circuits and systems. 11(6), 1290-1302. [8010351]. DOI: 10.1109/TBCAS.2017.2717281
     
22. Lim HH, Patrick JF, Lenarz T. Current Progress with Auditory Midbrain Implants. In: Scientific Foundations of Audiology, Perspectives from Physics, Biology, Modeling and Medicine, edited by Cacace AT, de Kleine E, Holt AG, van Dijk P. Published by Plural Publishing, Inc., 2016.
     
23. Siahpoush S, Erfani Y, Rode T, Lim HH, Rouat J, Plourde E. "Improving neural decoding in the central auditory system using bio-inspired spectro-temporal representations and a generalized bilinear model". 37^th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 37: 5146-5150, 2015.
     
24. Lim HH, Shannon RV. "Two Laskers and Counting: Learning From the Past Enables Future Innovations With Central Neural Prostheses." Brain Stimulation, 8(3): 439-41, 2015. Invited Editorial Abstract
     
25. Lim HH, Lenarz T. "Auditory Midbrain Implant: Research and development towards a second clinical trial." Hearing Research 322: 212-223, 2015. Abstract
     
26. Markovitz CD, Smith BT, Gloeckner CD, Lim HH. "Investigating a new neuromodulation treatment for brain disorders using synchronized activation of multimodal pathways." Scientific Reports 5: 9462, 2015. Abstract
     
27. Berding G, Wilke F, Rode T, Haense C, Joseph G, Meyer GJ, Mamach M, Lenarz M, Geworski L, Bengel FM, Lenarz T, Lim HH.  "Positron emission tomography imaging reveals auditory and frontal cortical regions involved with speech perception and loudness adaptation."  PLoS One 10(6): e0128743, 2015. Abstract
     
28. Czanner G, Sarma SV, Ba D, Eden UT, Wu W, Eskandar E, Lim HH, Temeranca S, Suzuki WA, Brown EN.  "Measuring the signal-to-noise ratio of a neuron."  Proceedings of the National Academy of Sciences of the USA 112(23): 7141-7146, 2015. Abstract
     
29. Plourde E, Rode T, Lim HH.  "A contribution of trained parameters to the goodness of fit of a Bayesian neural encoding model for the auditory system." Proceedings of the 7th International IEEE EMBS Conference on Neural Engineering 7: 910-913, 2015.Abstract
     
30. Straka MM, Hughes R, Lee P, Lim HH.  "Descending and tonotopic projection patterns from the auditory cortex to the inferior colliculus."  Neuroscience 300: 325-337, 2015. Abstract
     
31. Markovitz CD, Hogan PS, Wesen KA, Lim HH. "Pairing broadband noise with cortical stimulation induces extensive suppression of ascending sensory activity." Journal of Neural Engineering, 12(2), 2015. Abstract
     
32. Offutt SJ, Ryan KJ, Konop AE, Lim HH. "Suppression and facilitation of auditory neurons through coordinated acoustic and midbrain stimulation: investigating a deep brain stimulator for tinnitus." Journal of Neural Engineering, 11(6), 2014. Abstract
     
33. Straka MM, Schmitz S, Lim HH. "Response features across the auditory midbrain reveal an organization consistent with a dual lemniscal pathway." Journal of Neurophysiology, 112(4): 981-98, 2014. Abstract
     
34. Straka MM, McMahon M, Markovitz CD, Lim HH. "Effects of location and timing of co-activated neurons in the auditory midbrain on cortical activity: implications for a new central auditory prosthesis." Journal of Neural Engineering, 11(4), 2014. Abstract
     
35. Straka MM, Schendel D, Lim HH. "Neural integration and enhancement from the inferior colliculus up to different layers of auditory cortex." Journal of Neurophysiology, 110(4): 1009-1020, 2013. Abstract
     
36. Gloeckner CD, Smith BT, Markovitz CD, Lim HH. "A new concept for non-invasive tinnitus treatment utilizing multimodal pathways." Proceedings of the 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 3122-3125, 2013. Abstract
     
37. Calixto R, Salamat B, Rode T, Hartmann T, Volckaerts B, Ruther P, Lenarz T, Lim HH. "Investigation of a new electrode array technology for a central auditory prosthesis." PLoS One, 8(12), 2013. Abstract
     
38. Rode T, Hartmann T, Hubka P, Scheper V, Lenarz M, Lenarz T, Kral A, Lim HH. "Neural representation in the auditory midbrain of the envelope of vocalizations based on a peripheral ear model." Frontiers in Neural Circuits, 7(166), 2013. Abstract
     
39. Markovitz CD, Tang TT, Lim HH. "Tonotopic and localized pathways form primary auditory cortex to the central nucleus of the inferior colliculus."  Frontiers in Neural Circuits, 7(77), 2013. Abstract
     
40. Johnson MD, Lim HH, Netoff TI, Connolly AT, Johnson N, Roy A, Holt A, Lim KO, Carey JR, Vitek JL, He B. "Neuromodulation for brain disorders: Challenges and opportunities." IEEE Transactions on Biomedical Engineering, 60(3): 610-624, 2013. Abstract
     
41. Lim HH, Lenarz M, Joseph G, Lenarz T. "Frequency representation within the human brain: Stability versus plasticity." Scientific Reports, 3: 1474, 2013. Abstract
     
42. McKay CM, Lim HH, Lenarz T. "Temporal processing in the auditory system: Insights form the auditory midbrain implantees." Journal of the Association for Research in Otolaryngology 14: 103-124, 2013. Abstract
     
43. Markovitz CD, Tang TT, Edge DP, Lim HH. "Three-dimensional brain reconstruction of in vivo electrode tracks for neuroscience and neural prosthetic applications." Frontiers in Neural Circuits, 6(39), 2012. Abstract
     
44. Calixto R, Lenarz M, Neuheiser A, Scheper V, Lenarz T, Lim HH. "Co-activation of different neurons along the isofrequency laminae of the inferior colliculus elicits enhanced cortical activation." Journal of Neurophysiology 108: 1199-1210, 2012. Abstract
     
45. Lim HH, Lenarz M, Lenarz T. Midbrain Auditory Prostheses. In: Auditory Prostheses: Cochlear Implants and Beyond, edited by Zeng F-G, Fay RR and Popper AN. Published by Springer as part of the Handbook of Auditory Research, 2011.
     
46. Neuheiser A, Lenarz M, Reuter G, Calixto R, Nolte I, Lenarz T, Lim HH. "Effects of pulse phase duration and location of stimulation within the inferior colliculus on auditory cortical evoked potentials in a guinea pig model." Journal of the Association for Research in Otolaryngology 11: 689-708, 2010. Abstract
     
47. Zhang K, Wenzel GI, Balster S, Lim HH, Lubatschowski H, Lenarz T, Ertmer W, Reuter G. "Optoacoustic induced vibrations within the inner ear." Optics Express, 17(25): 23037-23043, 2009. Abstract
     
48. Lenarz T, Lim HH, Joseph G, Reuter G, Lenarz M. [Central auditory prosthesis]. HNO 57(6): 551-562, 2009. Abstract
     
49. Wenzel GI, Balster S, Zhang K, Lim HH, Reich U, Massow O, Lubatschowski H, Ertmer W, Lenarz T, Reuter G. "Green laser light activates the inner ear." Journal of Biomedical Optics, 14(4): 044007, 2009. Abstract
     
50. Lim HH, Lenarz M, Lenarz T. Auditory midbrain implant: A review. Trends in Amplification 13(3): 149-180, 2009. Abstract
     
51. Lim HH, Lenarz M, Lenarz T. A New Auditory Prosthesis Using Deep Brain Stimulation: Development and Implementation. In: Implantable Neural Prostheses: Techniques and Applications, edited by Zhou D and Greenbaum E. Published by Springer as part of the Biological and Medical Physics: Biomedical Engineering Series, 2009.
     
52. Lim HH, Lenarz T, Anderson DJ, Lenarz M. "The Auditory Midbrain Implant: Effects of electrode location." Hearing Research, 242: 74-85, 2008. Abstract
     
53. Lim HH, Lenarz T, Joseph G, Battmer RD, Patrick JF, Lenarz M. "Effects of phase duration and pulse rate on loudness and pitch percepts in the first auditory midbrain implant patients: Comparison to cochlear implant and auditory brainstem implant results." Neuroscience, 154(1): 370-380, 2008. Abstract
     
54. Lenarz T, Lim HH, Lenarz M. The Auditory Midbrain Implant: Experimental and clinical results. In: Recent Advances in Otolaryngology, edited by Kier J, Moffat DA and Studhoff H. Published by The Royal Society of Medicine Press as part of the Recent Advances Series, 2008.
     
55. Czanner G, Dreyer AA, Eden UT, Wirth S, Lim HH, Suzuki WA, Brown EN. "Dynamic models of neural spiking activity." Proceedings of the 46th IEEE Conference on Decision & Control, 5812-5817, 2007.
     
56. Lim HH, Lenarz T, Joseph G, Battmer RD, Samii A, Samii M, Patrick JF, Lenarz M. "Electrical stimulation of the midbrain for hearing restoration: Insight into the functional organization of the human central auditory system." Journal of Neuroscience, 27(49): 13541-13551, 2007. Abstract
     
57. Lenarz M, Lim HH, Reuter G, Reich U, Marquardt N, Klingberg MN, Paasche G, Lenarz T, Stan A. "Auditory Midbrain Implant: Histomorphological effects of long-term implantation and electrical stimulation of a new DBS array." Otology & Neurotology, 28: 1045-1052, 2007. Abstract
     
58. Lim HH, Anderson DJ. "Spatially distinct functional output regions within the central nucleus of the inferior colliculus: Implications for an Auditory Midbrain Implant." Journal of Neuroscience, 27(32): 8733-8743, 2007. Abstract
     
59. Lim HH, Anderson DJ. "Antidromic activation reveals tonotopically organized projections from primary auditory cortex to the central nucleus of the inferior colliculus in guinea pig." Journal of Neurophysiology, 97: 1413-1427, 2007. Abstract
     
60. Samii A, Lenarz M, Majdani O, Lim HH, Samii M, Lenarz T. "Auditory Midbrain Implant - A combined approach for vestibular schwannoma surgery and device implantation."  Otology & Neurotology, 28: 31-38, 2007. Abstract
     
61. Lenarz M, Lim HH, Patrick JF, Anderson DJ, Lenarz T. "Electrophysiological validation of a human prototype auditory midbrain implant (AMI) in a guinea pig model." Journal of the Association for Research in Otolaryngology, 7: 383-398, 2006. Abstract
     
62. Lenarz T, Lim HH, Reuter G, Patrick JF, Lenarz M. "The Auditory Midbrain Implant (AMI): A new auditory prosthesis for neural deafness. Concept and device description." Otology& Neurotology, 27: 840-845, 2006. Abstract
     
63. Lim HH, Anderson DJ. "Auditory cortical responses to electrical stimulation of the inferior colliculus: Implications for an auditory midbrain implant." Journal of Neurophysiology, 96: 975-988, 2006. Abstract
     
64. Lim HH, Anderson DJ. "Feasibility experiments for the development of a midbrain auditory prosthesis." Proceedings of the 1st International IEEE EMBS Conference on Neural Engineering, 193-196, 2003.
     
65. Lim HH, DeLano FA, Schmid-Schonbein GW. "Life and death cell labeling in the microcirculation of the spontaneously hypertensive rat". Journal of Vascular Research 38: 228-236, 2001.